How Will Pregnancy Affect Your Migraines?

Migraine Treatment During Pregnancy

For most women, migraine improves during pregnancy, especially for those who have migraine without aura. Studies show that migraine without aura improves after the first three months of pregnancy for about 60-70 percent of women. This is the case especially if your migraine has been linked to your menstrual cycle. If you experience migraine with aura you are more likely to have attacks during your pregnancy. If you experience migraine for the first time while you are pregnant, it is likely to be with aura.

During pregnancy, the steady and high levels of estrogen help protect against migraine. However, not all women experience less migraine during their pregnancy. I was one of those women during my last pregnancy. My first trimester was marked by daily migraines. I had to see a neurologist and have an MRI done to figure out what was causing them.

Nothing out of the ordinary was found. Most likely it was due to the hormonal changes that come with the pregnancy. I didn’t have a treatment plan in place before the pregnancy because I was still episodic and used OTC medications for acute attacks. It took some time to put one together afterward, but my doctors and I found a workable plan.

I was prescribed a preventive medication that was safe to take during my pregnancy and helped to manage the daily migraines I was experiencing during my first trimester. The frequency and duration of attacks went down significantly into my second and third trimesters. Whether that was due to the medication or just from the natural progression of my pregnancy, I cannot say. What did happen is that I was able to enjoy the rest of my pregnancy with fewer migraine attacks.


Migraine Treatment Guidelines

Here are some guidelines on what a migraine treatment plan should include and what to avoid during pregnancy. Always discuss your options with your obstetrician, neurologist, and/or your primary care physician before beginning or stopping any medications or treatments.

What should the treatment plan include?

  • How to treat acute migraine attacks and what is safe to take.
  • Which prevention medications can be taken.
  • The use of non-medicinal treatments.

What is safe to use for the treatment of acute migraine attacks?

  • Tylenol (acetaminophen)
  • Caffeine
  • Anti-nausea medications (Phenergan, Zofran, Reglan)
  • Tylenol with Codeine, Vicodin, Fioricet as rescues for severe migraine attack
  • IV fluids
  • IV Magnesium, IV Cortisol, IV Zofran, or Reglan
  • Triptans such as Imitrex ONLY if approved by your obstetrician

What should be avoided?

  • Aspirin
  • Anti-inflammatories (Motrin and Aleve)
  • Ergotamines (Cafergot, Ergostat, Migranal Nasal Spray)
  • Excessive use of narcotics (hydrocodone)

Which prevention medications should be avoided during pregnancy?

  • ACE inhibitors and ARB’s (blood pressure medications)
  • Depakote
  • Topamax (increased risk of cleft palate)

Which non-medicinal preventive treatments can be used?

  • Acupuncture
  • Massage
  • Physical Therapy
  • Biofeedback
  • Eating a balanced diet
  • Staying hydrated
  • Exercising regularly
  • Stress-reduction exercises

The use of occipital nerve blocks can help for a prolonged migraine attack during pregnancy. The anesthetic, which is injected superficially into the occipitalis region of the scalp, does not go into the bloodstream and therefore does not affect the fetus.

Non-drug therapies should be tried first to treat migraine in women who are pregnant. These would include relaxation, sleep, massage, ice packs, and biofeedback. For treatment of acute migraine attacks, acetaminophen suppositories are considered the first choice of drug treatment. The risks associated with aspirin and ibuprofen are considered small when taken episodically and if avoided during the last trimester.

Triptans, dihydroergotamine, and ergotamine are contraindicated in women who are pregnant. Prochlorperazine for nausea is unlikely to be harmful during pregnancy. Metoclopramide is probably acceptable during the second and third trimester. Prophylactic (preventive) treatment is rarely indicated and the only drugs that can be given during pregnancy are the beta-blockers metoprolol and propranolol.

Complementary and Alternative Medicine

Some women prefer complementary and alternative medicines during their pregnancies, believing homeopathic and herbal remedies are gentler and have fewer side effects. Just as conventional medicines can have unwanted side effects, so can some complementary treatments.

All complementary medicines should be taken under the supervision of a practitioner. For example, rosemary essential oil needs to be avoided with aromatherapy massage, as well as cinnamon, clove, and clary sage, all of which can cause contractions. Reflexology is not advisable during pregnancy as it is believed to cause miscarriage. Feverfew should not be used during pregnancy as it can cause contractions.


If you are or will be breastfeeding your baby, it is best to avoid medications as much as possible because they will be passed on to the baby through the milk. Drugs used during the pregnancy can be taken when breastfeeding, except for aspirin. Aspirin could impair blood clotting in babies who may have this issue so it is best to be avoided.

If you need to take aspirin or the anti-nausea drug metoclopramide, do not breastfeed for 24 hours after the last dose. If you can, store breastmilk in the freezer for such occasions. Any milk expressed while on these medications will need to be thrown away. Otherwise, use formula until you can breastfeed again.

The same applies to the triptans almotriptan, eletriptan, frovatriptan, rizatriptan, and sumatriptan. They are licensed to use during breastfeeding if you do not breastfeed within 24 hours of the last dose. Again, you may need to “pump and dump,” but if you keep extra milk stored in the freezer you can still give your baby breastmilk.

If you are planning a pregnancy and are taking regular medication for your migraine, talk to your doctor(s) on the best way to manage your migraine before and during the pregnancy, after the birth of your baby, and while you are breastfeeding.

Resources (Managing Migraine During Pregnancy)

Drug Safety. U.S. National Library of Medicine (Migraine in Pregnancy: What Are the Safest Treatment Options?) 

The Migraine Trust (Pregnancy and Breastfeeding)

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